EUROMEDICAHanover29-30 Mai 2006 |
Advanced methods of diagnosis,
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European Academy of Natural Sciences, HanoverEuropean Scientific Society, HanoverRussian Academy of Natural Sciences, Moscow |
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| V.M. Plotnikov V.A. Rotov |
ASCORBATES OF BIOMETALS AND LITHIUM: WAYS OF REDUCING TOXICITY OF PSYCHOPHARMACEU TICALS |
| OOO «Biointermed», Moscow, Russia |
Development of new psychotherapeutical medications of high bioactivity and low toxicity is one of the primary issues for the modern psychopharmacology. The medications based on the salts of lithium widely used in the practice are known to produce substantial side effects. Thus, there is the necessity to develop new forms of lithium preparations.
The objective of the present work is to investigate the properties of a new lithium complex containing the ascorbic acid as a bioactive ligand, comparing to ascorbates of calcium and cobalt.
The study of the acute toxicity of the ascorbates of cobalt, calcium and lithium was carried out in comparison with a popular clinical medication – lithium carbonates in ВALB/C mice by intraperitoneal introduction of drug the water solutions of the above mentioned preparations with the method of probit analysis.
The study of immunomodulating effect of the preparations was carried out in the model of incomplete phagocytosis of neutrophilic leukocytes of the peripheral blood in healthy donors and in the reaction of blast transformation of the lymphocytes.
The comparable toxicity analysis of lithium ascorbate enabled to state that it is 2-3 times less toxic for the experimental animals as the pharmaceutical preparation of lithium carbonate as well as ascorbates of other metals. The results of estimation of the impact of the above mentioned preparations on incomplete phagocytosis of the leucocytes showed that after the effect of the ascorbates neutrophilic activity has increased by 50100% alongside with the absorbing ability of leucocytes in comparison to the lithium carbonate.
Therefore, new properties of lithium ascorbate are established attributing it as a biologically active substance with a low toxic effect. Hence its further preclinical trial is recommended
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