EUROMEDICA  Hanover 29-30  Mai 2006	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Chemical elements play important role in self-adjusted system of homeostasis. Stability of chemical compound is one of major and obligatory conditions of normal functioning of an organism. Deficiency, surplus or dysbalance of macro-microelements can be the consequence of many pathological conditions. Correction of macro-microelement status of an organism is possible due to use of functional foods (FF) as a source of mineral substances for dietic correction. Phytosorptional biostimulating complexes (PBC) influencing on the organism through lymphatic system have been developed in the Institute of Clinical and Experimental Lymphology SB RAMS within the complex program of rehabilitation medicine.

Resulting effect of the developed FF consist in three functions due to combined action of phyto- and sorbent components: 1. sorptional detoxication of the organism internal environment; 2. regulation of metabolism processes; 3. delivery of essential nutrients in bioaccessible form into the organism. FF “Harmony VITA G” is a source of macro-microelements providing an adequate level of daily consumption of Mn, Fe, P, Cu, Co, Ca, Mg, Zn, K.

The purpose of work was to estimate efficiency of the FF “Harmony VITA G” as the corrector of mineral salts dysbalance in an organism by way of research and quantitative definition of shifts in macro-microelement metabolism in biosubstrata (the blood whey, central lymph, tissues) in experimental models. Model 1: Medicamentous therapy of Diabetes Insipidus with Antidiuretic Hormone and support of phytocorrection in rats “rattus norvegicus” with phenotypical display of gene di (Diabetes Insipidus). Model 2: 2-monthly hypodinamia of rats of presenile age and 2-monthly hypodinamia of presenile rats with administration of the FF “Harmony VITA G”.

Methods: Atomic – emission spectrometry with arc excitation of spectra was used to definition of chemical compound of biological substrata. Procedure of the analysis included preliminary mineralization of test by dry ashing way. Definition was spent for 12 elements (Al, Ba, In, Ca, Cu, Fe, Mg, Mn, P, Pb, Sb, Zn). Model 1: Chemical compound of the blood whey and central lymph was defined. Model 2: Chemical compound of the blood whey, central lymph and hip adductor (muscle) was defined.

Results: Model 1: The obtained results testify that micronutrient balance between the lymph and blood is broken severely in animals with congenital defect of hydro - electrolyte homeostasis rattus norvegicus that leads to disturbances of immune homeostasis and drainage – detoxication properties of lymphatic system. Combined use of medicamentous therapy and phytodietcorrection promotes normalization of microelement balance between the lymph and blood providing restoration of the functional status of lymphatic system.

Model 2: Redistribution of the basic macro-microelements between liquid biosubstrata and tisssues is observed in conditions of hypodynamia, so steady growth of Са, Mg, Fe, P concentration is noted in the lymph and whey of blood with simultaneous significant decrease in the maintenance of these minerals in muscles. Phytodietcorrection promotes normalization of mineral structure of muscular tissue, maintenance of the muscles functional activity in condition of age hypodynamia.

Conclusions: Active correction of feed structure allows to solve the problem of normalization of the macro-microelement status of an organism with use of the developed functional foods in various pathologies.