EUROMEDICA  Hanover 29-30  Mai 2006	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Lymphatic system plays the important role in development of many diseases. Infringement of its drainage abilities and a state of an interstitial connecting tissue occupies a significant place in a pathogenesis of endotoxicosis. Therefore studying of mechanisms of infringements of lymphatic system with a substantiation of lymphotropic correction and prophylaxis is highly actual.

It was found out by us that the toxic lesion of a liver is accompanied by accumulation of products of lipid peroxidation in the central lymph, and also decrease of α-tocopherol content which is compensated by increase of hepatocuprein that testifies about lymphatic resetting of the last one and replacement of α-tocopherol in reactions of lipid peroxidation in conditions of an oxidative stress. Reduction of function activity of liver after chronic toxic influence is activated by enteral usage of sorbents (enterosorbents, enterosorbent plus lipolitic enzyme lipoorizine, combination of enterosorbent and an aqueous extract of vegetative polyphenolic compounds) that is confirmed by the decrease of an expressiveness of serum markers of damage of a liver, augmentation of rate of microsomal metabolism of xenobiotics, decrease of activity of lipid peroxidation in the central lymph, plasma and liver microsomal fractions.

On the basis of experimental investigations we developed approaches to correction of drug lesions of a liver at patients with pulmonary tuberculosis, method of an assessment of haemolympocirculation in liver, method of lymphotropic therapy of patients with chronic virus hepatitis.

Data obtained as a result of the present research allow us to set the points of the pathogenic applications of lymphotropic-sorbent technologies up at a chronic hepatitis. It is necessary to use the methods of correction rendering sanogenic influence via lymphatic system and reacting in all parts of lymphatic region of a liver in treatment of patients with chronic hepatitis. Enterosorbents and sorption drugs influence a drainage of tissues, carry out a prosthetic repair of function of lymphatic frames, sorb toxins and interfere their enterohepatic circulation, reduce metabolic overload on organs of metabolism and excretion (first of all, liver). Application of a complex of polyphenolic compounds as lymphostimulators and lymphocorrectors influences on drainage and detoxicative function of lymphatic system, prevents development of an oxidative stress. Method of regional lymphotropic therapy provides direct transfer of drugs to liver, intensifying pharmakodynamic effects of medicinal preparations, and also stimulates a lymphatic drainage of tissues of a liver.

Complex application of methods of lymphsanation provides supporting of homeostatic constants due to introduction in cells of a liver first of all antioxidants and erasion of decomposition product and a metabolism, carrying out perfusion of cells. The lymphatic system in such statement of a question is not only one of components of the macroorganism, but the effective instrument in hands of the clinician. All-level influence on lymphatic system activates sanogenic processes in lymphatic region of the affected organ, due to modulation of antioxidant protection, erasions of highreactive oxygenated products of disintegration, reduction of optimal conditions of functioning of the cascade of enzymatic reactions in a cell. It creates new prospects of treatment and prophylaxis of various diseases, but with the uniform common approach from position of clinical and preventive lymphology