EUROMEDICA  Hanover 29-30  Mai 2006	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Female milk protein Lactoferrin by having very obvious antibacterial properties is a very attractive biotechnology product as it can be used in baby nutrition as well as in pharmacology and cosmetology. Annual world market for lactoferrin is estimated at the level of $6,5 billion dollars.

Babies on artificial nutrition when treated with human lactoferrin will increase antivirus and anti-microbe immune status until the full own immune system is formed. Specialists think that goat milk with lactoferrin can by 10 times reduce mortality rate due to gastroenteritis among babies on artificial nutrition.

Institute of Gene Biology, Russian Academy of Sciences within the Intergovernmental program (Russia-Belarus) has created gene constructions that allow to produce economically viable volume of human lactoferrin in the milk of transgenic animals. Transgenic laboratory mice have average expression of human lactoferrin in their milk as high as 10-20 g/l, with a maximum of 40 g/l. Maximum concentration of lactoferrin in women’s milk is only 5 g/l.

Research has shown that transgene and the expression level of human lactoferrin are inherited by several generations. The human lactoferrin produced in the milk of transgenic animals had the same physical and chemical properties as the lactoferrin from female milk.

At present an extended effort is under way to make primary transgenic goats that produce human lactoferrin with their milk.

Upon initial quality assessment of prime transgenic goats the best producers will be chosen that will start the new breed of goats with human lactoferrin in their milk.

Goat milk is hypo allergic and well assimilated.

Goat milk with human lactoferrin will be the first commercial product as a dietetic artificial nutrition for babies. Research on the goat milk lyophilizing technology has started.