EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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With the purpose of raising treatment effectiveness in patients with contusive changes of the rear of the eye a therapy based on injections of drugs into posterior pole of eyeball – the retrobulbar area through the irrigation system was developed at our cathedra. The possibility of constant-flow drug infusion with the help of autonomous portable impulse dosator was studied.

Clinical trials were carried out during acute period of eye contusion (217 children aged 5-14 years - 217 eyes.) The characters of changes of the fundus: marked edema, contusion zones of the retina in 94 persons - 94 eyes; hemorrhagic component in 82 patients - 82 eyes; hypotony and detachment of choroid in 41 patients, 41 eyes. The treatment of the patients was conducted with 3 methods for introduction of medications due to which 3 observations groups were formed:

The first group was treated with intermittent introduction of drugs into the irrigation system - the retrobulbar area by means of insulin dosator in the form of a 15-second injection performed 4 times per hour (95 eyes). Infusions of 0,06 ml rate per an infusion were carried out within 8-10 hours reaching a daily infusion volume of 2-2,5 ml.

The second group was treated with 5-fold retrobulbar infusions of drugs through the irrigation (67 eyes).

The third group was treated with one-fold retrobulbar infusions (65 eyes).

Due to comparative analysis of the treatment dynamics in three groups it was stated that the beginning of the positive outcome in the third groups took place on the second day, in the second group on the third-forth day and in the third group on the forth-fifth day. In the patients treated according to our method the recovery took place 3-4 days earlier than in the second group and 6-7 days earlier than in the third group. The period of hematoma resorption was 16-18 days in the first group, 27-28 days – in the second group and 41-45 days in the third group. The choroid in conjunction with its exfoliation was attached: in the first group - 6-7 days earlier that in the second group and twice as quick as in the patients who underwent traditional introduction of drugs. The maximal vision acuity resulting from the intensive treatment of the patients of the first group was achieved on 9-15 day with the acuity indices of 0,9-1,0; in the II group it took 13-19 days with the indices 0,75 - 0,85; whereas in the third group it took 18 - 25 days with the acuity 0,6 -0,7.

The clinical data confirmed a high efficiency of this method. The use of dosator for the therapy of the acute conditions enables to introduce a wide combination of drugs as well as response flexibly to the conditions of the patient. Carrying a dosator by no means restricts a patient’s mobility and introduction of the drugs during the day does not evoke painful sensations.