EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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The aim of this work was the control of sterility and the trial of possible antibacterial activity of the dermatological cream (DC) «Mustela» (TS 9158-001-13008948-99).

The control of sterility in the glass tubes with the liquid peptone medium, supplemented with 0,1 ml of DC and in Petri dishes with peptone agar, supplemented with 1, 2, 10, 50 ml of DC, was carried out. The samples of DC were incubed at 37 °C during 24-48 hrs. The each experiment was carried out immediately after opening the package and after its storage during 5-6 months at 21°C.

The antimicrobial activity of DC against the strains of S. marcescens, E. agglomerans, C. freundii, H. alvei,

K. pneumoniae, S. arizonae, P. alcalifaciens, Y. enterocolitica, B. cereus, S. aureus, E. coli, P. aeruginosa and P. vulgaris was investigated. The bacterial test-cultures from 4 till 24 hrs were cultivated and used in concentrations of 10⁹, 10⁵, 10³ and 101 CFU/ml. The microbial cultures on the media without the DC served as the control. The bacterial cultures during 24-48 hrs at 37 °C were incubed.

The data achieved indicate that the samples of DC after opening the package and after its storage during 5-6 months at 21°C were sterile. Antibacterial activity against 4 hrs cultures of S. marcescens, E. agglomerans and S. aureus on the dishes with peptone agar, supplemented with 2% of DC was established. The cultures of another species of bacteria survived in the presence of 1, 2, 50 and 100% of DC «Mustela».