EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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One of the important factors regulating expression of the different phenotypic features of muscle fibers (MF) is the nerve influence on skeletal muscle. Motor neurons control endogenous program of MF differentiation, maintain expression established characteristics in the mature MF and modulate skeletal muscle plasticity limited by MF phenotype. The role of humoral factors in regulation MF phenotype is important as well and it has much more significance for the conditions of neurotrophic disorders. The question of hormonal regulation of regeneration in the motor neuron-skeletal muscle system remains poorly investigated, although effects of hormones on the denervated muscle may be one of the crucial factors for the MF successive reinnervation. Based on these steroid and thyroid hormones which directly regulate gene expression have an important scientific interest. In our experiments it was detected that L-thyroxin prevents the decrease of fast MF in guinea pigs after sciatic nerve severing. On the model of sciatic nerve crush injury in ovariectomized mice it was shown that in mice receiving 17 -estradiol functional recovery of skeletal muscle began a week earlier than in the control mice. Our findings suggest that exogenous L-thyroxin and 17β-estradiol save the MF phenotypic features and stimulate muscle reinnervation after nerve injury