EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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In the northern regions man has to adapt to the cold. Frequent exposure to cold puts the problem of study of its health effects. The important role belongs to the lymphatic system providing the maintenance of the immune homeostasis. The lymphatic node is considered as a medium pressing marker. The study of the lymphatic node structure during the adaptation to the cold at the conditions of Western Siberia and Antarctic has a scientific interest. But the study will not be complete if the scientist will not try to control the process of cold adaptation with the help of lymphatic system. Bioflavonoids of the adaptogenous herbs as an option of functional food are offered to use for this purpose.

The experimental model of cold exposure is related to the intermittent severe (IS) type adaptation. This model is the most physiologic and comparable to the situation, when man is exposed to the cold.

The different extreme climatic and geographic regions cause not the same type adaptive transformation of the lymphatic node. The additive cold exposure differentiates from the structural changes of the lymphatic node in the studied regions of Western Siberia and Antarctic. It is marked that the IS type adaptation of the lymphatic node structures in the different regions processes in different ways in comparison with initial level. The morphologic kinetics of the lymphatic node structures during the IS type adaptation is determined with the climatic and geographic conditions of Western Siberia and Antarctic. In Siberia it is manifested by increasing the capsule and paracortex and by decreasing the sinus system in comparison with the initial indexes during the first month of study. In Antarctic the area of cortical substance is decreased and the area of sinus system is increased during the first month of study, then all indexes produced a stable decrease at the third month of study. It shows so-called “inversing” of the indexes in the different climatic and geographic regions. Simultaneously, the “minimization” of the lymphatic node structures is demonstrated that is characteristic of the severe natural conditions of Antarctic.

The fixed fact of the different answers of the lymphatic system shows the effort of the adaptation mechanism of the organism during the sub- and extreme conditions. So the main purpose of the medicine is to remove this effort and to increase the resistance against the destabilizing factors. The use of the herbal flavonoids in various ways improves the parameters of the lymphatic node structures. When the herbal bioflavonoids are used, the lymphatic nodes with the intermediate and compact morphologic type are predominated. This fact proves evidence of activation of the immune and drainage characteristics of the lymphatic node.

Undoubtedly, the herbal flavonoids as elements of functional food have the lymphotropic and immune properties. When the bioflavonoids are used, the universality of the structural changes of the lymphatic node is achieved, ensuring optimal functioning of the lymphatic node. The lymphotropic technologies of the phytoprevention are effective for increasing of the adaptive ability of organism and for optimizing the process of adaptation at the level of the structures of the «lymphatic region» at the conditions of the continuous environmental changes. The described effects of the herbal flavonoids create the prerequisites for their wide application in sub- and extreme natural conditions.