EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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The diseases of paradontium and etiologically connected partial teeth lack are the most common in economically developed countries. Their pathogenic mechanisms depend on the state of a non-specific organism’s resistance, immunity, factors of antioxidant protection and a microelement homeostasis. Our studies show that the damage of paradontium tissues is accompanied with the high effort of regulatory mechanisms. So the pathology of maxillodental system is considered to be not only of a local character but is also connected with the organism’s reaction and possible interaction between pathology of the oral cavity and systematic diseases.

Nevertheless just a quantitative increase of medical manipulations and medications is no guarantee for an effective therapy. Since the high effort of adaptive abilities is displayed in the course of diseases of the maxillofacial system, the therapy must be directed not only against the symptoms but also to separate functional systems and organism in whole. The high therapeutic efficiency of the local use of selective ion-exchanger for treatment of chronic catarrhal gingivitis in children is demonstrated. Maxillary applications of selective ion-exchanger on the base of natural zeolite in combination with professional hygiene of oral cavity lead to positive changes in essential microelements content of oral liquid. This was manifested by the optimization in the content of significant microelements and a moderate increase in iron by 20%, phosphorus - by 30%, copper - by 22%, and selenium - by 48%. The use of “Immudon” in a complex treatment of chronic catarrhal gingivitis raised the treatment efficiency. The clinic indexes are improved in comparison with the indexes of control group. PMA (papillary-marginal-alveolar) index is decreased in 2,8 times; Rumfierd index is decreased in 2,4 times. The laboratory indexes were also improved. Leukocyte modulating activity was decreased in 1,76 times; antioxidant activity is increased in 1,8 times.

The use of a phytomineral complex during the dental implantation leads to optimization of lymphocyte energy charge. Activity change of succinate dehydrogenase (SDG) is insignificant. Minimum of 18,54±0,44 was observed on the 60^th day of the study; maximum of 21,40±0,93 was detected on the 30^th day of the study. This quality of phytomineral complex is very important because it guarantees moderate increase of SDG activity during the whole period of study. At the same time the moderate increase in the activity of cytoplasmatic and mitochondrial α-glycerophosphate dehydrogenase (GPDG) by 25% and a synchronic interaction of cytoplasmatic and mitochondrial components of glycerophosphate shunt were observed. The described dynamics shows an increase of co-coordination of various ferments for cell energy charge that enables the cell to spare protein catalysts. The immune modulating therapy is necessary as well as effective measures for correction of inflammatory and adaptive processes in the oral cavity, followed by a prevention system and an effective treatment of diseases of the maxillodental system.