EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Lungs carry out various metabolic functions alongside with respiratory. The role of lungs in lipid metabolism after taking food is not studied enough. Triglycerides (ТG) enter the digestive tract and split up into fat acids and β-monoglycerides under the influence of lipase and bilious acids in proximal department of small intestine. TG are resynthezised and included into the structure of chylomicrons (CM) in endoplasmatic reticulum. CM go into lymphatic capillaries of intestinal fibers, therefrom - into the central lymphatic channel and then - into the system of superior cave vein. Hence lungs are the first organs on the way of CM formed after food intake.

The purpose of our investigation was to study participation of lungs in recycling of TG in structure of CМ after taking food.

The research was carried out on 24 nonlinear male rats in the age 4 months with body weight 370 - 420 g. The animals have been divided into two groups. The first group consisted of 13 rats which were not given food during 12 hours before acute experiment. The second group consisted of 11 rats which were given lard (in the rate of 1g on 100 g of body weight) 2 hours prior to acute experiment. The carotid artery was opened under ethaminal narcosis and 3 ml of blood were taken, then the clip was imposed on the artery and the thorax was opened, the heart was naked and blood was taken from the right auricle. The blood was centrifuged. TG were defined in plasma by the way of enzyme calorimetric test.

Results of the research proved that plasma of rats blood from right auricle and carotid artery does not differ authentically in maintenance of TG (0,60±0,05 mmol/ l and 0,66±0,10 mmol/l accordingly) on an empty stomach. TG concentration in blood plasma from the right auricle was higher than in blood plasma from the carotid (1,20±0,16 mmol/l and 0,77±0,11 mmol/l accordingly; p <0.05) in the second group in 2 hours after taking lard.

Obtained data testify that lungs actively participate in TG recycling after a food intake. They seem to protect an organism from increased TG input into arterial channel. Lipoproteinlipases and heparin from lungs capillaries are likely to play an active role in this process.