EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Objective: To study a role of hemodynamics for ROP development.

Materials and methods: in children’s department of the intensive care unit 290 premature infants were investigated. All treatment methods included oxygentherapy. Indirect ophthalmoscopy was applied, the data of a cerebral blood flow was assessed, in particularly the dopplergraphic index - an index of anterior cerebral artery resistance (the norm of 0,68-0,72).

Results: in the children who were born at 25 - 27 weeks gestation an arterial spasm was detected in 82 %, at 28 - 29 weeks - 67 %, at 30 - 32 weeks - 54 %. Signs of venous outflow obstruction that is venous plethora is attributed to older newborns.

At vessels of the retina in norm the index of resistance of the anterior cerebral artery in average came to 0,67 + 0,02; at arterial spasm - 0,77 + 0,02. The index was higher in children of smaller gestational age at birth and lower in more mature infants. At 25 – 26 weeks gestations the index of frontal brain artery resistance came to 0,8 + 0,02; at 28 weeks 0,78 + 0,03; at 30 - 31 weeks 0,74 + 0,02; at prematurity 32 weeks - 0,69 + 0,04. Before the development and in the course of ROP progression the index raised and was in average within 0, 84 + 0,02. And, the more active was the progression of the disease, the higher was the index (up to 0,9 - 1).

Conclusions: These data reveals a significant role of cerebral blood flow disturbances for the development of retinal pathology. The prevalence of hyperoxia-associated symptoms in very premature infants might signal an inadequate oxygen amount.