EUROMEDICA  Hanover 1-2  Juni 2007	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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It is known that neurotrophic control disorder causes in skeletal muscles various disturbances of their morpho-functional properties. Thus, motor nerve transection or axon transport blockade lead to enlargement of connective tissue part in the muscle, decrease in the diameter of muscle fibers, change of qualitative content of contractile proteins, falling of fatigue resistance .All these changes are described as denervation syndrome.

Temporomandibular join dysfunction is one of the most often occured pathologies of maxillofacial apparatus, wherein there is disorder of masticatory muscles functioning. Foci of contracture, potions of hyperextension and physiological disturbances of contraction processes appear in case of such dysfunction in masticatory muscles. At the same time, it’s not exactly clear what changes are happening on the morphological level under these circumstances. We studied the biopsies of masticatory muscles of the patients with temporomandibular joint dysfunction. Classic morphological and immunohisochemical study of qualitative myosin content in these muscles in patients with prolonged course had found changes similar to those, appearing in case of neurotrophic control disorder. Compatible results were obtained during investigation of fatigue resistance in these muscles. According to activity of Krebs cycle enzymes, muscles were also verging to denervated ones. Therefore, in conditions of temporomandibular joint dysfunction the muscles are in the same condition as appearing in case of neural trophicity disorder.