EUROMEDICAHanover6-7 Juni 2008 |
Advanced methods of diagnosis,
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European Academy of Natural Sciences, HanoverEuropean Scientific Society, HanoverRussian Academy of Natural Sciences, Moscow |
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| A.Y. Falkovskaya V.F. Mordovin P.I. Lukyanenok E.V. Tsmbalyuk |
EARLY CEREBROVASCULAR DISORDERS IN TYPE 2 DIABETIC PATIENTS WITH CEREBROVASCULAR DISORDERS IN TYPE 2 DIABETIC PATIENTS WITH HYPERTENSION |
| Research Institute of Cardiology of Tomsk, Russia |
Introduction: It is known that diabetes mellitus (DM) is a strong predictor of stroke, however role of metabolic factors and profile of blood pressure (BP) in development of early cerebrovascular disorder in hypertensive diabetic patients is proof known.
Objective: The aim of this study was to define the role of both metabolic changes and blood pressure in development of early cerebrovascular injury in patients with combined arterial hypertension (AH) and diabetes mellitus (DM).
Methods: 51 patients with AH and DM type 2 (10 males, aged 40 to 61 y.o.) were enrolled in this study. 24-hours ambulatory blood pressure monitoring (AMAD) and MRI of brain, assay of plasma levels of the lipids, HbA1 were performed in all patients.
Results: Besides the role of the severity of AH (duration of AH, level of systolic BP- 24h, systolic BPnigthtime, pulse BP-24h) in the degree of the periventricular leucoaraiosis, multiple linear regression analysis revealed statistically significant correlation of the latter with both the duration of DM and the level basal glicemia. Noteworthy, the expression of the others
MRI markers of cerebrovascular disorders depended only on the parameters of AMAD. Specifically, there was correlation between global ventricles volume of the brain and level of systolic BP-24h (R=0,42, p<0.05) and load of systolic BP-daytime (R=0,34, p<0,05). Moreover, the severity of intracranial hypertension depended on values of systolic BP-24h (R=0,5, p<0,001), load of systolic BP-24h (R=0,4, p<0,01), pulse BP-24h, and variability of diastolic BP daytime (R= 0,3, p= 0,04). Of interest, the number of focal white matter lesions positive zones correlated with the load of systolic BP-nighttime (R=0,44, p=0,013).
Conclusions: The degree of the cerebrovascular changes in patients with combined AH and DM strong correlate with the severity of AH, while abnormalities in carbohydrate metabolism contribute to periventricular leucoaraiosis.
| ASSOCIATION OF CEREBROVASKULAR DISORDER WITH ENDOTHELIAL DYSFUNCTION AND MICROALBUMINURIA | List of abstracts | DYNAMISCHER STUHL - RADIKALE METHODE DER KORREKTUR DER SITZHALTUNG DER KINDER |
