I. Trushkina
I. Plotnikova
G. Filippov |
LIPID ABNORMALITIES IN YOUNG PEOPLE WITH INCREASED
BLOOD PRESSURE |
| Research Institute of cardiology, Tomsk, Russia |
Overweight individuals are much more likely to have dyslipidemia and elevated
blood pressure. This clinical measures that dramatically increase risk for cardiovascular
and metabolic diseases. The aim of this study was to examine the extent of blood
lipid abnormalities in obese adolescents and to determine whether the prevalence
of dislipidemia is different in overweight teens with different forms of essential
arterial hypertension. Plasma lipid levels that were designated abnormal were
total cholesterol ≥ 5.2 mmol/l, triglyceride ≥ 1.1 mmol/l, low-density
lipoprotein ≥ 3.39 mmol/l and high-density lipoprotein < 1.17 for boys
and 1.3 for girls mmol/l. Plasma lipid data were available on 150 overweight
teens aged from 12 to 18 years, mean age 14,9 ±2,2 years. Based upon
daily AP monitoring, all patients were divided into 3 groups: the 1-st group
were 45 (30%) patients having “white coat” hypertension (WCH), the
2-nd one were 61 (40.7%) of patients with labile hypertension (LH) and the 3-rd
one were 44 (29.3%) of patients with stabile hypertension (SH). Twenty healthy
adolescents were controls. Patients with secondary hypertension did not enter
into the study. Compared to healthy controls, hypertensive patients had greater
levels of total cholesterol and low-density lipoprotein. The highest total cholesterol
levels were noted in those adolescents who subsequently developed stabile form
of hypertension (4.83±0.89 mmol/l, p=0.0003), levels in group with «white
coat hypertension» and of controls practically was differ (3.96±0.82
and 3.1 ±0.52 mmmol/l respect, p=0.0002). Within this overweight sample
of adolescents, the relationships of the recorded plasma lipid concentrations
with blood pressure levels were also examined. Using Pearson correlation analyses
there were statistically significant simple correlation coefficients,
plasma total cholesterol and low-density lipoproteins concentrations with systolic
blood pressure (r=0.52, p=0.006) and with high-density lipoprotein (r=-0.43,p=0.02).
A positive correlation was also observed between triglycerides and body mass
index (r=0.56, p= 0.002). Dislipidaemia was observed in 11.1% with «white
coat hypertension», 41% with labile form of arterial hypertension and
in 79.5% cases of stabile form. Atherogenic dyslipidemia usually precedes the
clinical manifestation of the metabolic syndrome.
