I. Plotnikova
I. Trushkina
T. Suslova
G. Filippov |
METABOLIC PROFILE OF ADOLESCENTS WITH ESSENTIAL ARTERIAL
HYPERTENSION |
| Research Institute of cardiology, Tomsk, Russia |
The clinical diagnosis of dysmetabolic syndrome in adolescents accelerates the
risk for cardiovascular events. These risk factors are being expressed at young
ages. In this study, we determine the prevalence of the components of metabolic
syndrome among adolescents aged 12-18 years from West Siberia. Data were analyzed
for 326 adolescents (70% males), mean age 14,9 ±2,2 years, who had an
increased blood pressure. The metabolic syndrome is defined as a constellation
of laboratory and physical findings such as raised triglyceride (≥1.13
mmol/l), reduced high-density lipoprotein-cholesterol (≤1.04 mmol/l ), raised
blood pressure ( ≥90
th percentile) and raised fasting plasma glucose
(≥6.1 mmol/l). Prevalence of the metabolic syndrome was estimated according
to the National Cholesterol Education Program Adult Treatment Panel III, using
NHANES III data. The control group consisted of 27 healthy adolescents. As the
components of the syndrome, frequency were as follows: 6,4% for abdominal obesity,
22,3% for elevated triglyceride, 34,7% for reduced high-density lipoprotein-cholesterol,
based upon daily AP monitoring 40% with labile form of arterial hypertension
and 30% with stabile form and 30% with «white-coat» hypertension.
Most of the hypertensive teens had hyperuricemia (74%), some of the patients
combined hyperuricemia with changes in glycemic profile of blood (14%).
Metabolic syndrome mono-markers were revealed in 66.6% of adolescents having
the phenomenon of “white coat hypertension” and in 78.3% of those
with labile hypertension. Only 7.4% of adolescents with essential hypertension
had no diagnosis signs of metabolic syndrome. Thus early diagnosis and treatment
of metabolic syndrome just in the stage of metabolic disturbances development
will allow to prevent such diseases as arterial hypertension, coronary artery
disease, diabetes mellitus of the 2-nd type.
