A.T. Dusembayeva
A.A. Idrisov
B.N. Nurmuhambetova |
MORPHOLOGICAL CHARACTERISTICS OF THYMUS AT CORRECTION OF EXOTOXICOSIS |
| Kazakh National Medical University, Almaty, Kazakhstan |
Actuality: In spite of a great number of works up to nowadays a thymus is considered
to be an organ with insufficiently studied structure and function, especially
in conditions of exotoxicosis and its correction. The aim of the work was a study
of microanatomic structure of thymus cellular compound exposing of benzpiren 3,4
and its correction. Material and methods: For creating an experimental model of
poisoning white “Vistar” rats were injected intra peritoneum per 3
days for 20mg/kg of body mass by minimal volume of olive oil (0.2-0.3 ml). After
injecting exotoxin animals were taking biologically active “Limfosan”
additions equally with standard ration at the dose of 1g/kg body mass. Animals
in control group were injected olive oil (benzpiren) intra peritoneum for 3 days.
The study of all animals were carried out in 1.7 and 21 days after poisoning by
benzpiren. An object of the study were pieces of thymus. Results of the study:
In 1 day after injecting of 3.4 – benzpiren at using Limfosan there were
marked an edema of thymus stroma and fat cells in the structure of interlobular
tissue. In the structure of light epithelial cells there was marked a reduction
of density number of free polysomal ribosoms and attached ribosoms density number.
A volume density of granular endoplasmatic reticulum cistern and filaments
volume density increased. In 7 days after introduction of 3.4 – benzpiren,
at using Limfosan there was marked a small edema of thymus stroma. A volume density
of mitochondria increased in the structure of light epithelial cells. Volume density
of granular endoplasmatic reticulum cistern didn’t differ from the value
in control. Volume density of filaments increased. Volume density of secretory
vacuoles corresponded to the value in control. In the structure of huge medullary
epithelial cells there weren’t marked a reduction of free polysomal ribosoms
density number and attached ribosoms density number. Volume density of granular
endoplasmatic reticulum cistern didn’t differ from the volume in control.
Volume density of mitochondria and volume density if filaments were increased.
In the structure of blood capillaries endotheliocytes there weren’t marked
reliable changes in values of mitochondria volume density. There was determined
a reduction of free polysomal ribosoms density number. Density number of attached
ribosoms was less. Volume density of granular endoplasmatic reticulum cisterns
didn’t reliably change. Volume densities of all types of micropinocytose
vesicules weren’t reliably different from proper values in control. In 21
day after injecting 3.4 – benzpiren, at using Limfosan the structure of
thymus corresponded to the same of an intact animal. In the structure of light
epithelial cells there weren’t any reliable differences from control values.
In the structure of huge medullary epithelial cells there weren’t any reliable
differences from the structure of intact animals cells. In the structure of endothelial
blood capillaries there weren’t any reliable changes in values of all cytoplasmatic
organoids from control values. There was determined an increased number of mitosis
in the structure of thymus cortical substance. Thus, changes of microanatomic
structure of thymus and cellular compound in all structural – fuctional
zones at using Limfosan biologically active additions after introduction of 3.4
– benzpiren testified, that biologically active substances, included
into Limfosan compound stimulate proliferative processes in organ
