C. Kontorschikova
M. Vedunova
J. Efremenko
O. Maslenikov
I. Gribkova |
THE STATE OF REDOX AND ENDOGENIC INTOXICATION IN
METABOLIC SYNDROME |
| The Medical Academy of Nizhny Novgorod, Nizhny Novgorod,
Russia |
A study was done to assess the indices of endogenic intoxication and of redox
in metabolic syndrome (MS). There were examined 111 MS patients (60 men and
51 women) with the diagnosis of arterial hypertension, atherosclerosis and diabetes
mellitus type-2, age ranging from 50 to 70. These patients made up a metabolic
syndrome group (Intenational Diabetes Federation, 2005) according to their morphology-function
(waist volume, increased arterial pressure) and biochemical parameters (TG-
level, CHOL-HDLP and fasting glucose). There were received the following findings.
The content of substances with low and medium molecular mass (LMMMS), which
is known to be the most informative index of endogenic intoxication, was increased
by 64,87 % in plasma and by 25,90 % in erythrocytes in MS. There was established
casual relationship between the stage of endo-intoxication and severity of the
pathology. Oligopeptide concentration was increased by 14,4% making up 145,51+5,62mg/l,
the norm being 127,21+3,97mg/l and erythrocyte concentration – by 37,2
% making up 33,37+4,09 mg/l, the norm being 24,33+2,23mg/l. Metabolic syndrome
develops alongside intensification of free radicals processes. There was
revealed a double increase in products of lipid peroxidation and of oxidative
protein modification (OPM). There was determined a correlation between
OPM level and CHOL-HDLP quantity, correlation coefficient being 0,649.
Besides, MS is accompanied by double increase of free fatty acids in plasma.
To assess the detoxicating function the activity of glutation-transferase and
albumin binding capacity was studied. Albumin reserve was found to be decreased
by 13% compared with the norm, while glutation-transferase activity was significantly
increased. Thus, the development of endogenic intoxication in metabolic syndrome
is interrelated with the accumulation of LMMMS, and of the products of oxidative
protein and lipid destruction.
