EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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For registration of the stages of adaptative reactions and control during the process of rehabilitation treatment simple indexes (leucocytic formula) are used. On the different amount of irritant an organism answers with different quality of adaptative reactions. In response to weak irritants general nonspecific reaction of training develops. The irritants of moderate force cause development of reaction of activating. It is characterized by the raise of protective and regulatory systems of the organism. Reduction of the laboratory examinations of patients to the common numerical value by means of the use of adaptative reactions not only allows to establish direction of dynamics of pathological process but also to differentiate the changes of indexes of “norm” in the child.

The purpose of our research was to develop the expert medical system, intended for the control and differential diagnostics of common nonspecific adaptative reactions of the organism in children with recurrent bronchitis RB), with the purpose of optimization of treatment under conditions of health resort.

Methods. For decision of the set problem the analysis of adaptative reactions (AR) was carried out by the signal indexes of leucocytic formula with the estimation of common levels of reactivity (LR) according to L.H.Garkavi with co-authors 1978 in 136 children from 7 to 14 years old, patients with RB at health resort. All children got traditional sanatorium-and-resort treatment with the use of climatic therapy, thalassotherapy, mud therapy and complex of preformation physical factors. For all children procedures of low intensity (low frequency physiotherapy, aeronotherapy), moderate intensity (laser irradiation) and procedures with strong effect (circular douche, sodium chloride baths) were included in the complex of rehabilitation measures taking into account rehabilitative reactions on admission.

Control of common nonspecific adaptative reactions of children with RB in dynamics and estimation of efficiency of therapy was carried out with the help of the developed by us system ADAPT Analyser 1.3 Lite.

Discussion. On admission in sanatorium in 63,89% of children with RB there was marked a tense reaction of training, in 30,43% - reaction of training with the low level of reactivity, that allowed us to consider their state as pre-disease, in 19,44% - a quiet reaction with tension, in 13,89% - stress, that was clinically manifested as ACD (in the first three days of stay in sanatorium), in 2,78% of children there was revealed a quiet activation without tension. It was earlier shown by us, that admistration to patients with the reaction of training with the low level of reactivity, strong procedures results in the failure of adaptation and development of acute respirator disease (ARD) in 37% of cases. Administration of therapy taking into account adaptative reactions allowed to find out on discharge a tense reaction of training in 38,89% of children, a quiet activation with tension - in 58,33%, a quiet activation without tension - in 2,78No one of the children showed a reaction- stress. In other words against a background of treatment in children with RB a quiet activation with tense began to occur 3 times as much more frequently, that was clinically manifested by the reduction of exacerbation of bronchitis 1,8 times less for subsequent 6 months.

Conclusions. Introduction of the program product - ADAPT Analyser 1.3 Lite, on the base of sanatorium allowed: to reveal children with the prenosologic states (predisease) on admission in sanatorium; to carry out sanatorium-and-resort treatment of children taking into account their adaptative – compensatory possibilities; to develop individually the complex of rehabilitation measures; to reduce morbidity of children with acute bronchitis.