EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Balsam “Graal” was created within in the frames of transnational program “To help Chernobil, 1987” and it is an aromatic 40°-alcoholic liquid from the medicinal plants, the Caucasian mountain and the red wine from the special vine breed.

It was registered at the Ministry of Heath in Ukraine and Byelorussia as a radioprotective, antistress, adaptogenic, antitoxic preparation against inflammation.

The results of the research of balsam’s antinarcotic action are represented in the practice.

The experiments were carried out on hybrid mice of both sexes, weighing 22-24gr. in the conditions of thermocomfort. The balsam was orally lead in the animal’s stomach by means of 1,3 and 10ml/kgr dozes, 1 hour before receiving the narcotic dose of ethanol (0,1ml 40 % spirit for 10 gr. body masses). The control animals were given the drinking water Placebo instead of preparation one hour before receiving ethanol.

We were estimating the functional tone of central nervous system by means of duration of losing an orthostatic reflex after receiving the ethanol, restoration of which was registered according to the animal’s side condition.

It is established that the balsam “Graal” has solid neiromatonized effect in the wide interval of dozes (from 1 to 10 ml/kgr.)

The part of mice (as a rule, 2-3 from the group) didn’t lose an orthostatic reflex when having a narcotic doze of ethanol, after receiving 3-10ml/krg preparation, which points out the fact that the balsam has clearcut neirostimulating effect.

Table 1 Neirostimulating action of the balsam on mice while estimating the ethanolic narcotic test

groups	doze ml/kgr.	the number of mice	the duration of narcosis M±m,min	the number of mice without the side condition*
1	control		37,7±-4,8	0/10
2	0,3		26,2±2,2**	0/10
3	1,0		16,3±3,0**	1/10
4	3,0	10,0	15,5±2,7**	3/10
5	10,0		19,6±1,2**	2/10

*the side condition isn’t placed (et P≤0,05)

** Trustworthy difference from the control The comparative examination of balsam and 40° ethanol has shown that the components of preparation weaken the neirodeprimatic action of ethil spirit. This deference becomes especially clear when the dozes of balsam and clean ethanol are comparatively low (8ml/kgr.). In this case 40% of animals doesn’t have the side condition, but for the rest the duration of narcosis lasts 12,8 minutes compared with the 24,2 minutes in control.

Table2 Comparative narcotic action of balsam and ethanol during an equal concentration of ethil spirit remark:designations are the same as in table 1

groups	doze ml/kgr.	the number of mice	the duration of narcosis M±m,min	the number of mice without the side condition*
ethanol 40°	10		31,4±4,1	0/10
balsam	10	10	22,0±3,4**	0/10
ethanol 40°	8		24,2±2,6**	1/10
balsam	8		12,8±1,5**	3/10

According to the received results we may conclude that balsam “Graal” has clearcut antinarcotics action, which can be a good base for creating an effective antiophiaticmeans.