EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Cadmium compounds are widely used in various industries, and rather significant working contingents are exposed to their professional influence.

In this connection present research studying comparative aggression cadmium sulfate in a doze of weight of a body of 0,5 mg / kg separately and in a mix with other poisons on parameters of a fatty, carbohydrate and mineral exchange was, and also studying of ability of a sulfate - ion to interfere with development of an intoxication.

In experiment was 4 groups of animals and two groups of control animals. The first group of animals received only cadmium, the second - cadmium and sulfate, the third - cadmium with a mix of substances (zinc, lead, iron, cooper, antimony, arsenic, fluorine in quantities which meet in manufacture of cadmium), the fourth - cadmium with a mix of substances and sulfate. Sulfate was entered, as well as all components, per os as a solution sodium sulfate at the rate of 25 mg SO₄² on kg of weight of a body of an animal. This quantity of sulfate approximately corresponded to its quantity acting in an organism at consumption of potable water with the maintenance of sulfate at a level of maximum concentration limit.

Duration of experiment - 4 months. All substances were entered per os daily, except for days off and holidays.

Every month blood of animals was taken to define the 11 biochemical parameters: the whole protein, urea, DNA, RNA, glucose, general lipids, the general cholesterol, conjugated cholesterol, diphenylamine reaction, calcium, inorganic phosphorus. Standard techniques stated in widely known manuals are used. The positive effect of sulfate was estimated by comparing parameters of the groups which were receiving and not receiving sulfate with the help of Student’s criterion.

Overall during experiment each group received it is 44 parameters (4 terms and 11 parameters).

During experiment the group receiving cadmium had 21 changes of parameters, 17 of them have undergone corrections under influence of sulfate; the group receiving cadmium with the mixture of substances had 17 changes, 14 of them have undergone corrections under influence of sulfate. Statistical processing with application of Fisher’s φ variable showed reliability of data on the positive influence of sulfate in both cases. The essential difference in amount of parameter changes or cases of positive influence of sulfate between groups of animals was not revealed. It gives the ground to consider that the degree of intoxication in action of cadmium and cadmium with a mixture of substances was approximately identical.