EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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It is known, that toxicity of this or that substance can change under influence of other substances and connections. Special interest in this matter attracts substances in a dose equal to the toxicity of poison, do not bring harm to an organism. One of such substances is the inorganic sulfate-ion, which favorable action on development of intoxication by many industrial poisons has been already shown earlier.

In the given work results of researches on biochemical parameters of rabbits blood of at an intoxication by cadmium in a doze of 0,1 mg/kg of body weight per day, and also the same amount of cadmium in a combination with mixture including zinc, lead, iron, cuprum, antimony, arsenic, fluorine in amounts which is met in the manufacture of cadmium, and influence of a sulfate-ion as sodium sulfate in amount of 25 mg SO₄ on kg of body weight on development of an intoxication by these substances is investigated. The amount of sulfate approximately met its enter into an organism by consumption of potable water with the sulfate content at a level of maximum concentration limit.

Duration of experiment is 4 months. All substances were entered per os daily, except for days off and holidays.

The first group of animals received only cadmium, the second - cadmium and sulfate, the third - cadmium with a mixture of substances, the fourth - cadmium with a mixture of substances and sulfate. There were also two groups of intact animals.

Every month in the body of the animals 11 biochemical parameters of blood were determined: the whole protein, urea, DNA, RNA, glucose, general lipids, the general cholesterol, conjugate cholesterol, diphenylamine reaction, calcium, inorganic phosphorus. Widely known techniques recommended by the respective manuals are used. A positive effect of sulfate established by comparison of parameters of the groups which were receiving and not receiving sulfate with the help of Student’s criterion.

In each group of animals during experiment 44 parameters were obtained (4 terms and 11 parameters).

For the period of experiment the group receiving cadmium had 11 changes of parameters, from which 7 under the action of sulfate have undergone corrections; in the group receiving cadmium with a mixture of substances there were 22 changes, 10 from them have undergone corrections with the help of sulfate. Statistical processing with application of Fisher’s φ variable has shown the reliability of data on the positive influence of sulfate in both cases, however in relation to amount of the changed parameters in group with a mixture of substances the cases of positive influence of sulfate was less. Moreover, the significant amount of parameters changes in group with a mixture of substances allows to say that the mixture of substances aggravates action of cadmium.