EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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For the last decade due to the vigorous development of industry there has been the considerable increase of heavy metals in the environment that affect organisms of animals, plants and human beings. Lymphatic nodes are of important significance in protective reactions of the organism under the conditions of endotoxicosis. All of the above mentioned results in necessity of working out a complex program of lymphosanation, detoxication and endoecological rehabilitation of population with application of new conceptual approaches to sanation of the organism through the lymphatic system.

Material and methods

In experiment male rats of Vistar race (weight range 180-200 g) were used. The animals were divided into 3 groups. The first - control one included the animals, receiving standard vivar ration for 2,5 months. The second group was composed of the animals, taking vivar ration but with addition of cadmium in the dose of 1,5 mg per kg of weight for the same period of time. In the third group after developing the model of chronic cadmium intoxication Tagan-sorbent in the dose of 1g per kg of body mass was added in the standard vivar ration for 30 days. The animals were decapitated in 1,7,14 and 21 days after the experiment a caudal mesenterial lymphatic node was taken for histological investigation as object of study.

In the second group of animals in all the studied zones of the lymphatic node there was observed an increase of macrophages number, elevated lympoidcytolysis, particularly in the centers of multiplying the secondary lymphoid nodules. In the cerebral lines there were found Mott cells. A macrophage reaction was observed in the cerebral sinuses. The number of thick cells increased two-folds.

In the animals of the third group in comparison to the second one there was decrease of degenerating cells, macrophages, thick cells, number but an increase of a medium lymphocytes number. Mitotic cells activity raised. Restoration of the lymphatic node structure was observed by the end of the experiment.

Thus, correction of exotoxicosis by Tagan-sorbent does not prevent dystrophic changes in the lymphatic area of the colon. The coregent action is manifested in restoring the colon structure.