EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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Aim. To study effects of a cardioselective beta-adrenoblocker bisoprolol on vascular wall endothelium function and external respiration function in stable angina of effort combined with chronic obstructive pulmonary disease (COPD).

Material and methods. Endothelial function and external respiration were studied before and after 4-week treatment with bisoprolol in 36 patients with stable angina and COPD using assessment of endothelium-dependent vasodilatation (EDVD) and concentration of nitric oxide metabolites.

Results. Before the treatment EDVD was 3,11+1,23%, after the treatment EDVD became 4,94+1,43% (р<0,05). Initially the concentration of nitric oxide metabolites in blood consisted of: NO₂ – 15,73±2,54 mkmoll/L, NO₃ – 17,19±3,51 mkmoll/L; after 4-weeks of treatment became NO₂ 18,53±1,97 mkmoll/L, NO₃ – 20,92±1,8 mkmoll/L. Significant improvement of endothelial function was achieved due to 4-week bisoprolol treatment which did not affect external respiration function.

Conclusion. Bisoprolol is an effective and safe drug in the treatment of stable angina combined with COPD. It can noticeably improve endothelial function.