EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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The purpose of persisting studies was an estimation of the influence of the use of Tagan sorbent on contents of the urea and creatinine in shelters of the rats, at exposure to different doses of clorous cadmium, for determination of the functional condition of these animals.

The experiments were conducted on white non-pedigree rats. Clorous cadmium was given daily with provender in 2 groups of the rats (on 1,5 mg/kg accordingly and 3,0 mg/kg), for 2,5 months. Then these groups were divided each on 2 parts. 2 from four groups got Tagansorbent (on 1,0 g/kg weight daily, for a month in composition with standard ration). Remained two groups received during a month a standard ration. Then, on 1, 7, 14, 21 day after completion of the intake of the sorbent, 2-3 rats from each group withdrew for undertaking experiment. Besides in each animal were taken the tests samples from abdominal aorta. In tests there were researched contents of the urea and creatinine.

In rate contents of urea in shelters of the rats varies from 2,5-8,3 mmol/l. The contents of the urea in shelters decreased, in contrast with checking level. So, at the first day, in response to reception of 1,5 mg/kg CdCl2 urea fell by 15%, by the end of the first week - by 18%, the second week - on 60% nearly, but by the end of observations - by 33% (that much lower compared to the second week) to the source level. However, intake of 3,0 mg/kg CdCl2 brought about reduction to the first day by 8%, by the end of the first week by 41%, the second week - by 60%, and, by the end of observations - by 35%. That is to say if exposure to cadmium resulted in reduction of the functional activity of the liver, synthesizing urea then at getting a higher dose of toxin did not occur as expected, more cutting the reduction of the contents of the urea in shelters that though and does not deny the fact of the reduction to functional activity liver. Otherwise it is possible to expect the joining of the reduction to functional activity, to reduction of the activities liver with increase the dose of toxin.

It was stated that intake of Tagan sorbent greatly reduced the biochemical shifts in shelters of the rats, appeared in response to chronic influence of the different doses of clorous cadmium (1,5 and 3,0 mg/kg on masses of the body animal).

If, influence of CdCl2 brought about reduction in the functional activity in liver of the rats, the use of Tagan sorbent rendered an essential protecting influence. Approximation to source level on background of the sorbent of the contents of the urea in shelters of the rats confirms this fact. However if contents of the urea in shelters exceeds the source level, which occurs after influence of a higher cadmium dose, by the end of observations, than this fact can speak as well as about a damage of the secretory function at intake of 3,0 mg/kgs Sd. From the literary it is known that under increasing of the contents of the urea there is damage in plasma shelters.

Therefore, using Tagan sorbent renders the positive influence upon condition of the liver, however animal are more sensitive to damaging action of the toxin. For this reason positive influence of the sorbent on activity of this organ was revealed only at intake of a small dose of toxin.