EUROMEDICA  Hanover 6-7  Juni 2008	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Russian Academy of Natural Sciences, Moscow

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The question of medical prevention of intoxications is not descending from the agenda for many years. For a long time Kazakhstan studied the ability of a sulfate-ion to interfere the development of an intoxication by various industrial poisons. Efficiency of a sulfate-ion is proven at intoxication by lead, white phosphorus, zinc etc.

In the present message results of study of sulfate-ion influence on the development of intoxication by cadmium at isolated action and combination with other elements that exist in a working zone at the enterprise manufacturing cadmium.

Two series of experiments were carried out. The circuit of experiments was identical in both series, with the exception that in the first series cadmium was entered into an animal in amount of 0,1 mg/kg, in the second – in the amount of 0,5 mg/kg. The mixture of substances consisted of the following components: zinc - 0,5 mg/kg; lead - 0,4 mg/kg; iron - 0,5 mg/kg; cooper - 0,3 mg/kg; antimony - 0,05 mg/kg; arsenic - 0,25 mg/kg; fluorine -1,0 mg/kg.

The sulfate-ion entered into the animal as a solution of sodium sulfate at the rate of 25 mg SO₄² to the kg of the animal body weight. This amount approximately corresponds to receipt of sulfate into the organism by consumption of potable water with the sulfate - ion content at a level of maximum concentration limit.

All substances were entered per os as a solution of salts within 4 months daily except for days off and holidays.

The first group of each series received only cadmium, the second - cadmium and the mixture of substances, the third - cadmium and sulfate, the fourth - cadmium, the mixture of substances and sulfate. The fifth group was control.

Every month blood of animals was taken to define the following parameters: the whole protein, urea, DNA, RNA, glucose, general lipids, the general cholesterol, conjugated cholesterol, diphenylamine reaction, inorganic phosphorus, calcium of blood. The assessment of sulfate influence was carried out by comparing parameters of the groups which were receiving and not receiving it with the help of Student’s criterion. The difference of percentage parameters was determined by the application of Fisher’s φ variable.

In each group of animals during experiment 44 parameters were obtained (4 terms and 11 parameters). The group receiving cadmium of 0,1 mg/kg had changes in 11 parameters from 44, 7 of them have undergone corrections by sulfate. The group receiving the same amount of cadmium and a mixture had changes of 22 parameters, 10 of them have undergone corrections by sulfate. The group receiving cadmium of 0,5 mg/kg had 21 changes of parameters, 17 of them have undergone corrections by sulfate. The group receiving 0,5 mg/kg cadmium and a mixture had 17 changes, 14 of them have undergone corrections by sulfate. Protective action of sulfate was statistically significant in both cases.

Thus, protective action of sulfate is determined at isolated action of cadmium in both investigated doses, and at its combinations with other elements.