EUROMEDICA  Hanover 3-4  Juni 2010	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Berliner Medizinischen Gesellschaft, Berlin

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Special researches show, that over 80 % of the population has parodentium (Kovalevskij A.M. 1996; Glickman J., 1972.). It is common, that chronic periodontitis proceed on a background of changes of the immune status of patients. The immune and metabolic characteristic of an oral liquid study will allow to prove terms and splinting of mobile prostheses methods in complex treatment of parodentium diseases. In this connection the purpose of research was studying immune and metabolic parameters of an oral liquid “up to” and “after” splintage of teeth.

86 patients aged 25-50 with chronic periodontitis years old, which have been divided into three groups. The first group was made by 75 patients with the phenomena chronic periodontitis, group of the control of 11 patients with intact paradentium, group of comparison of 56 patients which have received treatment under the standard scheme, and 19 patients which received complex treatment with splintage of teeth. All patients were without the expressed accompanying pathology. The lime content of interleukins (Il-4, Il-6), secretory immunoglobulin A (SigA) determine an oral liquid.

At a traditional method of treatment concentration of anti-inflammatory cytokine Il-4, Il-6 it is statistically significant decreased during treatment within a month (Il-4 on 26,4%; Il-6 on 90,5%) in comparison with control group. In 6 months later of supervision specified concentration Il-4 tended to increase, and concentration Il-6 is statistically significant exceeded a parameter of control group on 13,7%. Concentration SigA also it is statistically significant increases for 6,2%. At inclusion in treatment splintage of teeth concentration anti-inflammatory cytokines Il-4, Il-6 in a month of supervision authentically decreased (Il-4 on 13,2%; Il-6 on 73,2%) in comparison with concentration before treatment. In the remote terms of supervision (6 months later) Marked statistically significant decrease in concentration cytokines (Il-4 on 111,6%; Il-6 on 190,5%). Concentration SigA it is statistically significant decreased after treatment a month later on 91,47%, and statistically significant decrease in the given parameter on 114,73% in comparison with concentration before treatment is marked 6 months later.

Thus, at carrying out of complex treatment with splintage of teeth of chronic periodontitis are marked an average degree of weight statistically significant dynamics of concentration Il-4, Il-6, SigA and restoration of cytokine balance of an oral liquid.