EUROMEDICA  Hanover 3-4  Juni 2010	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Berliner Medizinischen Gesellschaft, Berlin

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The choice of lipoperoxidation substrata - free fatty acids (FFA) as endotoxicosis markers allows to study processes of lymphodetoxication as a link in the mechanism of an oxidising homeostasis under conditions of chronic and acute lymphtoxicosis. Methods of highly effective gas-liquid chromatography and chromato-mass spectrometry were used for studying of accumulation and distribution of FFA as elements of estimation of pro-antioxidant balance in the central lymph and blood of rats under conditions of their physiological pregnancy in end and fading of the reproductive cycle, experimental adentia, toxic hepatitis and their non-medicamentous correction.

The analysis of FFA pools and their share distribution has revealed development of oxidising stress under conditions of physiological pregnancy. The obtained data show expressed lymphotoxicosis and testify to stability in experimental dynamics of processes of lipid peroxidation (LP) and in antioxidant balance in the blood as compared with the central lymph.

The analysis of FFA accumulation, of the cumulative contribution of reactionary pathogenic non-saturated FFA and the share contribution of the LP basic substratum – arachidonic acid in the tests of the central lymph and peripheral blood shows the greatest development of oxidizing stress at strengthening of pro-oxidant processes in the central lymph. Defects of the tooth alignment cause insufficient mechanical and biochemical processing of food and constant alimentary damage of a mucous membrane of the digestive channel that leads to pathogenic LP activation and, as consequence, to development of chronic lymphotoxicosis and tissue pathogenic damages in the lymphatic region of a small intestine.

The comparative analysis of accumulation of general FFA pool and distributions of share contributions of acids in the tests of the central lymph and blood under conditions of a toxic hepatitis has revealed pathological activation of lipid peroxidation and development of acute lymphotoxicosis. Conditions of adaptation failure have allowed revealing the mechanism of dump of a part of the modified lymph with the prevailing maintenance of the acids incapable to oxidation in a blood channel. This mechanism, obviously, regulates important for achievement of an oxidizing homeostasis constancy of FFA share contributions in the blood, compensating endotoxicosis development.

The defeat of lymphatic system is caused by development of lymphotoxicosis and easing of drainage-detoxication function that predetermines necessity of search of ways of restoration of pathological shifts in the microhabitat cell surrounding. Studying of accumulation and profiles of FFA distribution allows not only estimating depth of LP pathological activation and development of lymphotoxicosis as a stage of endotoxicosis, but also estimation of efficiency of the improving means.

Features of influence are revealed and the estimation of efficiency of electromagnetic radiation of shortwave frequencies and of the natural complex «Harmony of Forces» was carried out for study of stabilisation of the LP processes in intact animals. Lymphoprotective action of the complex «Harmony of Forces» and of combined correction is shown. In the subgroup of the pregnancy which has come after influence on animal of electromagnetic radiation of short-wave frequencies set of the obtained data about the FFA pool and a parity of share contributions specifies in the expressed easing of activity of oxidizing processes in the central lymph.

It is shown that use of the complex «Harmony of Forces» for previous to pregnancy dietological correction leads to the stationary LP level in the central lymph. Absence of the LP pathological activation in the central lymph is revealed at the pregnancy of the animals which have come after combined influence of electromagnetic radiation of short-wave frequencies and of the complex «Harmony of Forces». Set of the obtained data testifies to lymph-improving action of the chosen methods of correction.

Set of the obtained data about dynamics of the FFA distribution and accumulation in the tests of the central lymph and blood reveals easing of the LP pathological activation, development suppression of lymphotoxicosos and endotoxicosis as a whole at experimental adentia and a toxic hepatitis in rats, testifying to activation of mechanisms of reperative regenerations in the damaged tissue under the influence of electromagnetic radiation of short-wave frequencies. Studying of the FFA as markers of endotoxicosis and of development of oxidizing stress has proved efficiency of enteral application of the natural phyto-complex «Harmony of Forces», possessing antioxidant and sorbtional properties, for improvement of chronic and acute lymphotoxicosis. Realization of the mechanisms of lympho-detoxication and lympho-protection is revealed in the level of region of a small intestine.

It is shown that combined correction of physiological pregnancy, experimental adentia and a toxic hepatitis promotes easing of the LP pathological activation and restoration of oxidizing homeostasis in the most expressed way, rendering antioxidant, sorbtional and gastroprotective influence on the organism internal environment.