EUROMEDICA  Hanover 3-4  Juni 2010	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover Berliner Medizinischen Gesellschaft, Berlin

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Investigation of oxygen status and water metabolism has been carried out during the anesthetic in 30 female patients in emergency surgery and in early post-op period.

The arterial and venous oxygen content, blood circulation minute volume, oxygen delivery to the tissues and water content in the intracellular intercellular and intravascular sectors have been controlled before the operation, in the most traumatic moment of the operation, in a few first minutes after the operation and 12, 24 hours later. The patients were operated for acute pancreatitis and peritonitis.

Decreasing of arterial oxygen content to 85-90 % from age-related characteristics and decreasing of arterial-venous oxygen content difference to 30 % have been expected before operating, rise in blood circulation minute volume at the expense of high-grade tachycardia was noted in 12 patients. In 10 cases the blood circulation minute volume was in 10-15 % lower than age related norms despite of essential tachycardia, only in 8 operated patients the rates of blood circulation minute volume were near to age related ones. The oxygen delivery to the tissues was lower than age related in all cases, so metabolic acidosis was fixed in all cases too. The essential water deficiency was observed in all sectors. The arterial oxygen content was increased nearly to 100 % during the operation against the artificial lung ventilation and the elevated inhaled oxygen concentration, the arterial-venous oxygen content difference increased, vascular water concentration equalized due to infusion. Blood circulation minute volume and oxygen delivery were optimized, but were not approximated to age related characteristics.

The variations of oxygen delivery and transporting data were different in all cases in post-op period because the toxemia was not eliminated in spite of abdominal sanation. That is why only the intravascular and extracellular water concentrations were stabilized against the infusion therapy to the end of the first post-op day. The deficiency of oxygen delivery to the tissues, metabolic acidosis were steel remained. In 8 cases essential circulation hypodynamia and hyperdynamia in 6 cases preserved.

Finding data indicate high rate toxemia and water metabolism insufficient in patients with abdominal infection before the operation and in early post-op period, which were followed by expressed disturbances in oxygen transport and water metabolism even after the operation and in first days of post-op intensive care.