EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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It is shown that in the case of arterial hypertension, rheological properties of the main carriers of oxygen and metabolites in blood are disordered, though, in case of cerebral ischemic affections these changes are absent. With appearance of the newest methods of erythrocytes’ plastic properties research there also appeared a possibility to specify our conceptions about an intensity degree of hemodynamic disorders in the case of vascular system diseases.

Material and methods

In our research were 12 men, who suffered from an arterial hypertension, complicated with stenocardia, and 12 patients with myocardial infarction, 6 women and 6 men. A control group was 15 healthy patients of proper age, 12 men and 3 women. We have examined main rheological determinants of erythrocytes by straight adequate methods in whole blood. Deformability was examined by diffracting osmoscany method, aggregative properties – with the help of piezodynamic method in a microcuvette on installations. The methods used let us estimate not only integral indicators of erythrocytes’ deformability and aggregation, but also assess sphericity (S/V ratio), internal viscosity of erythrocytes, aggregations’ solidity and the speed of their spontaneous formation in whole equalized blood. The blood was taken from ulnar vein on an empty stomach in the morning into test tubes with heparin at 150 units/ml.

Results of research

Deformability index was heightened in both groups of patients. An Omyn indicator’s decrease in both groups of patients is noticed: (159±8) mOsm with arterial hypertension and myocardial infarction and (157±9) mOsm – with stenocardia against (148±7) mOsm in healthy people (p < 0,05). Subject to this proviso, a slight decrease of O’ indicator is mentioned: (397±9) mOsm and (393±10) mOsm accordingly against (404±12) mOsm in control. Regarding spontaneous aggregation, both minimal (an indicator Uo) and maximum (Oq) aggregates’ solidities to mechanical destruction increase, which leads to reliable increase of aggregation index from (1,2±0,4) rel.units in control to (2,3±0,5) rel. units in the case of infarction (p < 0,01) and (1,8±0,3) rel. units (p < 0,05) with stenocardia. Change of Omyn indicator is less pronounced, but increase of deformability, in comparison with men, is more significant. Strength properties of erythrocytes’ aggregations and the speed of their spontaneous formation are higher among women. So, the aggregation speed among women, who suffer from myocardial infarction, increases in 12%, while among men – only in 5%.

Discussion

Our research have shown an absence of significant changes of erythrocytes’ deformability among patients, who suffer from arterial hypertension with myocardial infarction and bouts of stenocardia, but, reliable change of erythrocytes’ sideview with decrease of S/V ratio (change of Omyn indicator) is mentioned, that is swelling of red cells, and also a tendency to dehydration of hemoglobin (O’ indicator), that is decrease of internal viscosity of erythrocyte. Regarding sex differences in dynamics of disease, we can presuppose that correction of deformative properties of erythrocytes among women occurs in a more pronounced way, in comparison with men. Though, a risk of ischemic affections, due to a heightened aggregation status among women, is higher.