EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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Introduction. Association of bronchial asthma (BA) and gastroesophageal reflux disease (GERD) leads to reciprocal deterioration of both diseases. This research is about laser therapy efficacy for treatment of patients with bronchial asthma associated with gastroesophageal reflux disease. The combination of low intensity laser radiation of different wavelength and methods has been used.

Materials and methods. Research was done in Voronezh hospital № 20. There were 60 patients with association of moderate and severe uncontrolled BA and GERD. They were divided into four groups. Patients of main group (19 patients) received pharmacotherapy, supravenous laser therapy (wavelength 0,63 micrometer, power 5 milliwatt, exposition 15 minutes) and laser irradiation (wavelength 0,89 micrometer, power 5 watt, frequency 80 Hz) on region of adrenal glands and epigastric region in 3 minutes. There were 10 diurnal procedures. 2 group (15) received pharmacotherapy and placebo. 3 group (21) received only pharmacotherapy. 4 group (12 healthy persons) were for estimation of normal data of indices. Standart clinical, X-ray, functional studies including spirometry, endoscopy, pH, biochemical and laboratory tests were carried out before treatment, after 12-14 days and 1, 6 and 12 months after treatment. Vegetative state was examined by data of heart rhythm variability with ECG recorder «VALENTA MN-08». Adrenal cortex hormones were analyzed by immunoenzyme automated method with apparatus «Emmulite».

Results. In 12-14 and 28-30 days after beginning of treatment there was a positive dynamic of most clinic and laboratory parameters: decrease of dyspnea from 2,74±0,04 to 2,21±0,04 at 12-14^th days and to 2,2±0,15 at 28-30^th days (p<0,05), patients noticed significant improvement of cough at 28-30^th days (p< 0,05), towards the end of period of treatment intensity of such symptoms as heartburn (47%), eructation (21%), dysphagia (9,8%) and it’s connection with changing of pose (29,5%) was decreased (p< 0,05). At 28-30^th days of treatment significant increase of cortisol, testosterone and estradiol level in blood was detected. Evident increase of vegetative reactivity (SDNN) in 46,7% (р=0,0002) and decrease of parasympathetic activity (rMSSD) in 31,8% (р<0,05) occurred. Beneficial dynamic of test indices had continued after 6 and 12 months. Invalid dynamic of clinic and laboratory data was in placebo group. In 3^th group there weren’t significant changes of tested indices.

Conclusion. Experimentation has shown that combination of basic pharmacotherapy and repeated courses of laser therapy has the best efficiency and the most evident beneficial effect on clinical course of BA associated with GERD because of alternate action and activation of adaptive and compensatory response. This method of treatment influences on different parts of pathogenesis of BA and GERD. Consequently, introduced method of treatment makes it possible to increase effectiveness of therapy, shorten patient’s stay in hospital, corrects level of hormones and vegetative imbalance as well as reduces drugs dose.