EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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Research objective – to clear up epidemiologic peculiarities of Helicobacter pylori infection (H.p.) in the citizens of a megapolis by the example of Moscow.

Research material and methods. Randomly chosen representatives of the working population of Moscow were checked for Helicobacter pylori (H.p.) infection within the limits of mass medical examinations. 1856 people at the age from 19 to 67 years old were included into the research, 1132 males and 724 females. The infection was diagnosed by the presence of specific anti-Helicobacter pylori IgG antibodies in the blood serum by way of enzyme-linked immunoelectrodiffusion essay (ELISA). Diagnostic tests of two types were used: H.р. IgG ELISA («BIOHIT», Finland) and Н.р. «Ecolab» (Moscow). Relation of total amount of IgM, IgA and IgG antibodies to H.p. CagA antigen was established in 704 persons infected with H.p. with the help of HelicoBest-antibodies set (“VECTOR-BEST”, Novosibirsk). Each of the research participants was interviewed about their working activity, socioeconomic status, health status, living conditions at the moment of interview and in childhood, bad habits and hygienic habits, contacts with animals. The results were statistically processed with χ² Person criterion.

Results. 1615 persons, i.e. 87% of the research participants, were diagnosed with Н.р. infection. It was detected with equal frequency in males and females. Working citizens under the age of 30 were diagnosed with H.p. infection in 76% cases. The older the participants were the more of them were diagnosed with H.p. infection – up to 96% cases among participants over 60 years old. Anti-H.p. antibodies were seldomer detected in the participants with higher education than in those with elementary and secondary education, in office workers than in workmen. The share of infected participants among those who at work had been in contact with sewage waters was higher than among those who had not. Living in childhood in a village house without a sewerage system affected the frequency of H.p. infection. All the participants who lived in a communal appartment or hall of residence turned out to be infected. Influence of adherence to one of the principal hygiene rules – to wash hands before a meal – on how often antiboby-positive results were obtained was not established. Drinking tap water without boiling it did not affect contamination rate. Contact with pets did not lead to increase in contamination rate. Income per family member did not influence H.p. contamination rate, either. The cases of probable family contamination were often registered.

CagA antigen was detected in 81% of the H.p. infected.

Conclusion. H.p. infection prevalence among the working citizens of Moscow is extremely high. The infection is often to be detected in young people. Virulent strains of the bacterium predominate among the infected citizens of the megapolis. H.p. contamination risk factors are age, insufficient education, working as a workman, regular contact with sewage waters, living in a residence hall or communal apartment, and in childhood in a village house without conveniences.