EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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Constancy of internal environment of organism, his endo-ecological space, is supported by the lymphatic system, being one of the basic dedicated and self-regulating systems, that occupies an important place in the complex estimation of mechanism of the biological action on the organism of different destabilizing factors.

In the conditions of chronic exogenous intoxication a liver is most often struck -one of major organs of maintenance of homeostasis and detoxication of organism, and also her regional lymphatic apparatus. Metabolism of steroid hormones comes in hepatocytes, and if the presence of pathological process in a liver, may be violation of hormonal balance and, accordingly, processes of impregnation, offensive and flow of pregnancy. The lymphatic river-bed of liver drains her interstitial space. In the conditions of pathology - the role of river-bed increases considerably. The origin of failure in-process lymphatic river-bed at any states of organ always creates pre-conditions for development of endogenous intoxication. In the conducted experiment on the females of rats and their posterity (to pregnancy the model of chronic toxic hepatitis was created by complex influence of industrial ecotoxin factories – tetrachlormethane and 5% alcohol) morphological research of liver, her interstitial spaces (periportal spaces of Malla) and hepatic lymphatic nodes is conducted. At physiological pregnancy expansion of interstitial spaces is educed in the lobules of liver of mother (per sinusoidal spaces of Disse and periportal spaces of Malla), that can be explained by an edema and difficulty of lymphatic outflow from an abdominal region at pregnancy. Morphological picture of liver of mother at the pregnancy, complicated by chronic intoxication specific: the extended sine waves, diffuse and nodal leukocyte infiltration of parenchyma of liver, extended interstitial spaces of Malla (testify to stagnation of lymph and worsening of drainage function of the lymphatic system of organ), periportal scleroses, heterospecific macrophage granulosums round central veins, in composition that macrophages, desmocytes, much lymphocyte is revealed.

Research of liver at the pregnancy, complicated by chronic intoxication on a background a correction educed the effect of “metabolic lymph stimulation” (expansion of periportal spaces of Malla) preparation of “Essentsiale” at the level of tissue microregion of liver, providing the speed-up restructuration of organ. Analogical changes are educed in the liver of posterity from this group of rats: restructuration and activating processes of reparation, action of lymph correction in the lymphatic region of liver. In an experiment for the correction of chronic intoxication for pregnant animals the functional food “PikSil” was used. That is complex of bioflavonoid of medicinal plants: flowers of chamomile, balm, hips, grass of st.- john’s-wort and turn, sheets of bearberry and birch, fruits of fennel. This functional food was used as monotherapy and in a combination with “Essentiale”. Research of interstitial spaces (periportal spaces of Malla) in the liver of mothers with the complicated chronic intoxication on a background application of the functional food “PikSil “ showed diminishing of sizes of interstitium during the pregnancy as compared to an analogical index at the correction of “Essentiale” and at physiological pregnancy. The obtained data can testify that in the conditions of application of the functional food “PikSil” at the complicated pregnancy a lymph dynamic effect develops and drainage of interstitial space is accelerated at the level of tissue microregion of liver. Introduction of the functional food “PikSil” to the females at the pregnancy, complicated by chronic intoxication, hepatoprotective and lymph correction actions renders, assists renewal of structural-functional mutual relations in hepatic lymphatic nodes and liver for a mother and posterity.

Thus, combined introduction of “Essentiale” and functional food “PikSil” renders lymph correction action on hepatic lymph nodes and tissue micro district of a liver at the expense of activation of mechanisms metabolic and dynamic lymph stimulation.