EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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Range of industrial toxicants, which can meet the woman before and during pregnancy, is very wide. Annually humanity synthesizes tens of thousands of new chemical compounds, which are in contact with a man and interfere in its metabolism. Soil contaminated with chemicals, products of radioactive decay, the water in the aquifers contains dissolved heavy metals, often in concentrations exceeding the maximum allowable. It was heavy metals occupied the second place (after the pesticides) among the main pollutants of the environment. Their concentrations in the biosphere in 30-600 times higher than the background level and especially toxic is Pb. In modern toxicology estimates Pb refers to the first class of extremely dangerous for an organism. Reproductive toxicity of Pb is known for a long time, he easily overcomes gisto-blood barriers and the placenta, accumulates tissues of the fetus. Clinical and experimental studies carried out earlier in our institute, it is shown that many of the chronic diseases associated with health defects that have occurred even in the prenatal period. Long-term exposure of a pregnant woman with harmful chemical substances, leads to violation of fetoplacental complex and to the “vertical transmission” pathological processes in the body of the mother to the developing fetus and in fetus period are formed des-adoptive processes, which in the further life are implemented in immunodeficient in children, fast chronic pathological processes and the development of disease.

In this investigation, a study of the status of the lymphatic system during pregnancy complicated by chronic intoxication Pb acetate and on the background of application of NanoCarbon mineral sorbent (NCMS).

Only in the experiment used 90 female Wistar rats, which prior to the pregnancy was the introduction of Pb acetate (model toxic nephropathy) through a probe in the stomach every day in the dose of 20 mg/kg body weight in terms of the metal within 18 days. In the group of correction, during the pregnancy, administered enterally within 14 days NanoCarbon mineral sorbent. In this group of animals – before implantation fetal mortality was 11,11%, after implantation was 4,17%, and the total fetal mortality was 14,82%. Iliac lymph node in complicated chronic intoxication of pregnancy on the background of NCMS remains fragmented type of structural-functional specialization, it identifies structural signs of activation of the humoral and cell-mediated immune response. In the reduced thickness of the connective tissue structures, perhaps due to the reduction of edema. Investigation of the structure of the renal lymph nodes in the group of animals revealed reduction of transport through the lymph node (the area of the sinuses). In the renal lymph nodes identified pronounced structural signs of activation of humoral type of the immune response (increased area of secondary lymphoid nodules, the number of mature forms of cells of lymphoid and plasma- derived series).

Therefore, the use of sorbent to reduce the toxic load on the organism is extremely important, because many drugs are not recommended or even contraindicated during pregnancy. This study confirms that the use of sorbent in the complex of methods of drainage interstice, has expressed lymph correction and lymph stimulation effects.