EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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Annually humanity produces tens of thousands of new chemical compounds, which are in contact with a man, dwelling in his metabolic processes. Especially toxic among the heavy metals are lead, ranked as the first class of extremely hazardous substances. It is proved that lead has reproductive toxicity; this element easily crosses the placental barrier and accumulates fetus tissues (Nikitin A.P., 2005). Long-term exposure during pregnancy with harmful chemical substances, even subliminal values, resulting in damage to the placenta is formed in uterus des-adaptive processes, which are then implemented in pathological states are directly related to disturbances in mineral metabolism.

The purpose of the work: using multi-element analysis of blood serum to examine the state of the exchange of macro-and microelements in the organism with chronic intoxication salts lead to pregnancy.

Methods: analytical investigations were carried out by methods of atom-issue spectrometry. The chemical compound of the blood whey and lymph was defined on 11 elements (Al, Ca, Cu, Fe, K, Mg, Mn, Na, P, Pb, Zn). Biomarker: - blood serum. In the experiment used 90 female rats, which prior to the pregnancy, during 18 days, every day was the introduction of lead acetate solution through a tube into the stomach in a dose of 20 mg/kg body weight in terms of the meta, that corresponds to the 1 -2 mg lead.

Results and discussion: The obtained results testify that micronutrient balance of organism changes during physiological pregnancy. The maintenance of Ca, Cu and Na increase - on 25% and 10% accordingly, the reliable lowering of level of Fe, K, Mn and Zn in the serum of blood (40-10%) is marked. These changes are related to development and active functioning of feto-placental complex. The concentration of Pb in the serum of pregnant animals did not change as compared to a control group.

Considerably more serious disbalance of element exchange is found in the group of animals with leaden intoxication out of pregnancy (group A) and at condition of pregnancy by complicated leaden intoxication (group B).

Group A. Against a background the sharp increase of maintenance of Pb (70%) in blood, level of maintenance of all other elements except Al and Cu considerably decreases: Ca - 16%, Fe - 35%, Mg - 44%, K - 57%, Mn - 80%, Na - 25%, P - 8%, Zn - 80%.

Group B. At pregnancy by the complicated leaden intoxication maintenance of Pb in blood increases twice, the concentrations of other elements fall, both as compared to a control group and as compared to a group A: Al - 70%, Ca - 33%, Fe - 60%, K - 56%, Mg - 33%, Mn - 60%, Zn - 80%.

The carried out researches have shown that modeling of a lead intoxication, especially during pregnancy, leads to sharp disturbance of acid-base and water-electrolyte balances (to what change of a parity of sodium and potassium in a blood testifies), to redistribution of elements in system “mother-placenta- fetus” and to accumulation of the extremely toxic Pb in a blood.