EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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Background. Now gout is considered as important medical problem that is connected with the received data about influence of hyperuricemia on progressing of atherosclerotic defeat of vessels. Gout is metabolic disease, and hyperuricemia — one of the major components of a metabolic syndrome. The close interrelation between purine exchange disorders and hypertriglyceridemia is found out. Communication between hyperuricemia and insulin resistance is proved. Hyperuricemia it is independent risk factor of cardiovascular diseases and also disease complications, therefore, hyperuricemia diagnostics and gout treatment are an actual problem of therapy. The official data of gout in Republic of Sakha (Yakutia) are absent. This is a preliminary report on incidence of gout requiring hospitalization 2007-2010.

Methods. A research project has been initiated to determine the incidence and characteristics of gout in Yakutia from 2007-2012. Patients hospitalized in the department of rheumatology of Yakut City Hospital are being studied by means of a questionnaire developed by the Institute of Rheumatology (Moscow), which includes questions on anamnesis, form of gout, and specifics of treatment. Data also being collected include: laboratory measures (glucose, HDL-C, LDL-C, TC, TG, creatinine, urea, uric acid, TP, bilirubin, ALT, AST, GGTP, alkaline phosphatase, creatine kinase); urinalysis, on admission plus daily analysis of urine (creatinine, protein, uric acid); radiographic assessment of feet and wrists; ultrasound of kidneys.

Results. 2007 − 13 patients were registered, including 8 with secondary gout. The tophaseus form was observed in 5 patients. 2008 − 12 patients; 5 with secondary gout. The tophaseus form was observed in 2 patients. 2009 − 8 patients; 6 with secondary gout. 2010 − 6 patients; 2 with secondary gout. The tophaseus form was observed in 1 patient.

Conclusion. The research proceeds. Results will be used for characterization of incidence and diagnostic features of gout in the Republic of Sakha (Yakutia) with the goal of standardizing guidelines for diagnosis and treatment of gout, assuring optimal care for these patients.