EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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One of the main reasons of premature death of patients with chronic glomerulonephritis are cardiovascular disorders, which are known as acute and chronic types of ischaemic heart disease. It is impossible to eliminate existences of common hypercoagulative mechanism which is the basis for coronary arteries affection and glomerular microclotting formation.

The aim of research was estimation of pathological processes of clotting in patients with chronic glomerulonephritis and added chronic ischemic heart disease and determination of possibilities of management of such disorders by the use of liposomal remedies and interval normobaric hypoxic therapies in such combined pathology.

Methods and Results. 200 patients with chronic glomerulonephritis and concomitant ischaemic heart disease were included into this research. The general criteria of patients in research were presence of clinical, laboratory and/or morphological signs of chronic glomerulonephritis, mesangial proliferative, mesangiocappilary, focal and segmented types of glomerulonephritis without clinical and laboratory activity and nephrotic syndrome, chronic glomerulonephritis with arterial hypertension 1-2 degrees, chronic types of ischemic heart disease (stable angina 1-3 classes and painless myocardial ischemia), normal function of kidneys. The selected patients are divided into 4 groups according to age, sex and durations of both diseases.

After randomization and realization of complex of initial researches, the first group (50 patients) got the standard antianginal medications (nitrates, antagonists of calcium, statins, antiplatelet agents, beta-blockers, angiotensin-converting enzyme inhibitors) with daily 50-60 minute interval normobaric hypoxic therapy at 1112% oxygenating respiratory mixture. Second group (50 patients) got the same management, but in combination with liposomal remedies. “Lipin” in a dose 0,5 gr. on 50 ml of physiological solution of sodium chloride IV in the morning, and “Lipoflavon” - in the evening (produced by “Biolek”, Kharkiv, Ukraine).

For preparation of solution of “Lipoflavon” content of one bottle (solvent) carefully poured in another small bottle (lyophilizate), which was intensively shaken off during one minute to formation of homogeneous emulsion with next intravenous introduction. Additionally in the day-time 0,5 gr. “Lipin” was given to patents by inhalation with help ultrasonic nebulizer. The third group (50 patients) got triple therapy: standard antianginal medicines, interval normobaric hypoxic therapy and liposomal remedies according to the same scheme. A fourth group (group of comparison) got medicamental antianginal therapy only. All actual results of researches compared with fifty healthy people of analogical age and sex (control group).

Results. Patients with such combined pathology had the laboratory signs of hypercoagulative syndrome which showed up from one side in worsening viscosity properties of blood , and from other - the increase in number of platelets with hyperadhesion features. Influence of the different management on the state of platelet adhesion showed ability to diminish the percent of thrombocytes with increased adhesion with used liposomal remedies (2 group), but greater results showed up at combination of this treatment with interval normobaric hypoxic therapy

Conclusions. The patients with chronic glomerulonephritis and concomitant ischaemic heart disease have development of laboratory signs of hypercoagulative syndrome. Application in the complex treatment liposomal remedies showed decrease in blood viscosity viscidity of blood, red blood cell and platelet count in their hyperaggregation and hyperadhesive states. A maximal antiplatelet result was in patients with combined renocardiopathology after combined therapy with using of standard antianginal medicines, normobaric hypoxic therapy and liposomal remedies