EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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The rats of Vister and WKY type, which are hypertensive controlling animals of the type SHR, were examined for biochemical and physiological blood values during an exposure to a stressor (forced running on a treadmill at a speed of 14 m/min for 30 min every day for 1-2 weeks). Control animals were kept in usual inhabiting conditions.

After exposure to the stressor hematocrite volumes, concentration of erythrocytes in the blood, hemoglobin content, 2.3 DPA, the activity of ACH-ASE and concentration of glucose, cholesterol and triglycerides in the blood plasma were measured in all the animals. All experimental animals, which were exposed to a stressor, appeared to have an increased tendency to increased erythrocyte torori duality based levels on a certain increase in hemoglobin dehydration and internal viscosity levels, and, besides, a certain rate of decrease in formation of erythrocyte aggregation. The trained animals appeared to have a decreased tendency to decreased hemoglobin concentration and number of erythrocytes in blood as compared to the control animals.

The rats of SHR type showed an increase in the concentration of 2.3 BPG in erythrocytes, which indirectly gives an evidence of hypoxia signs. The content of ATP in erythrocytes, the activity of ACH-ASE and the concentration of triglycerides, cholesterol and glucose were not significantly changed in the blood plasma of these identical animals.

The rats of VISTER type had a tendency to decreased hematocrit volumes and a tendency to decreased concentration of cholesterol and triglycerides in the blood, hemoglobin concentration and number of erythrocyte, besides, the concentration of glucose in blood plasma and ACH-ASE activity of erythrocytes.

The information obtained indicates that exposing VISTAR rats to physical effects decreases oxygen (transport properties of the blood) to some extent. The WKY rats, on the contrary, show a tendency to increased biochemical blood values, which emphasizes a useful effect of running on a treadmill on a physical condition of these animals.

The observed tendency to increased hemoglobin dehydration and internal erythrocyte viscosity may possibly lead to a decrease in the speed of blood movement in the capillaries, which is the result of adaptation to hypoxia during running exercises.