EUROMEDICA  Hanover 23-24  Mai 2011	Advanced methods of diagnosis, treatment and prophylactics
	European Academy of Natural Sciences, Hanover European Scientific Society, Hanover

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The increasing interest to sepsis is conditioned with the high level of morbidity and mortality, which occurs as a result of delayed diagnostics. Therefore, the searching of early informative markers of systemic inflammation is quite actual.

Goal of study: To evaluate the diagnostic value of procalcitonin (PCT) in patients with diagnosed sepsis.

Methods: We investigated the level of PCT in 90 patients with sepsis in intensive care unit. Among them 73.3% (n=66) were males and 26.7% (n=24) were females, mean age compiled 43.8±17.1 years, mortality – 28.9% (n=26), the severity of condition according to APACHE II scale was 14.3±6.9, duration of hospitalization – 18.1±18.8 (2-116) days; main diagnosis on admission – polytrauma – 33.3% (n=30), peritonitis – 11.1% (n=10), gynecological pathology – 6.7% (n=6), and pneumonia – 48.8% (n=44).

For establishment of sepsis diagnosis the classification of ACCP\SCCM (Bone R.C., 1992) was used. PCT concentration in plasma was calculated during the establishment of diagnosis. Diagnostic levels were as following: <0.5 ng/ml – sepsis is excepted, 0.5-2.0 ng/ml – infection and sepsis are possible, 2.0-10.0 ng/ml – high probability of sepsis, >10.0 ng/ml – probability of sever sepsis, septic shock and polyorganic dysfunction.

Results According to the data obtained the levels of PCT were as follows: < 0,5 ng/ml - 48,9% (n=22); ≥ 0,5 - < 2,0 ng/ml - 11,1% (n=5); ≥ 2,0 - < 10,0 ng/ml - 20% (n=9) and > 10 ng/ml - 20% (n=9).

Discussion: In these categories the correlatrion of diagnosis by PCT is revealed in 40% (n=36) of cases, meanwhile, in 60% (n=54) of cases sepsis was diagnosed basing on ACCP\SCCM classification. Data obtained concerning the values of PCT testify that PCT is not a universal biochemical marker of the acute phase of inflammation.

Conclusion: The levels of PCT marker do not correspond to the clinical-microbiological bases of sepsis diagnosis, which testifies the need of further investigations in this area.